This page presents the three-dimensional (3D) genomics profiles during 3T3-L1 adipogenesis, as determined by Hi-C and promoter capture Hi-C (PCHi-C). It includes raw contact maps, A/B compartment assignments, topologically associating domain (TAD) boundaries, and chromatin loop annotations derived from Hi-C, as well as significant chromatin interactions involving promoter regions (resolved at the restriction fragment level) captured by PCHi-C. Given the current lack of a universally accepted consensus framework for quantitative differential analysis in 3D genomics, we opt not to directly provide differential analysis results. Instead, we supply the raw interaction profiles for each differentiation time point, enabling users to download the corresponding data files and conduct differential or downstream analyses customized to their specific research needs.
Distinct from other pages on this platform, the charts and visualizations here are generated on the backend. Users can specify either a genomic region or a specific gene to examine its surrounding chromatin spatial conformation. If a gene is selected, the displayed region will be centered on its transcription start site (TSS) with a radius of 1 Mb.