Adipome is a comprehensive multi-omics database that systematically maps the epigenomic and transcriptomic landscape of 3T3-L1 adipocyte differentiation. Integrating high-resolution data from chromatin accessibility, histone modifications, DNA methylation, transcription factor binding, 3D genome architecture, and gene expression across critical differentiation stages—from preadipocytes to mature lipid-laden adipocytes—Adipome provides an unprecedented temporal and molecular resolution of adipogenesis. Hosted on this interactive web platform, it enables researchers to explore dynamic regulatory networks, identify stage-specific epigenetic switches, and uncover master regulators driving fat cell development. Adipome serves as a foundational resource for dissecting the epigenetic basis of obesity, metabolic disorders, and regenerative medicine.